The Guardians of the Gems of Pure Light and the Gems of Pure Darkness. The MCF members Tracy, Wing, Daisy, and Skyla are guardians while other guardians are either allies to the girls or villains they face. Not all of the guardians, however, are awaken and not all of them have the gems they protect yet.

It is noted that there are many different genes as well due to Anya, Tracy's and Tricia's mother, and Stan having been a guardian as well in the past and Susan becoming a guardian in the future.

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